Interaction of calmodulin with Sec61a limits Ca leakage from the endoplasmic reticulum
نویسندگان
چکیده
Frank Erdmann, Nico Schäuble, Sven Lang, Martin Jung, Alf Honigmann, Mazen Ahmad, Johanna Dudek, Julia Benedix, Anke Harsman, Annika Kopp, Volkhard Helms, Adolfo Cavalié*, Richard Wagner* and Richard Zimmermann* Biophysics, Osnabrück University, Osnabrück, Germany, Medical Biochemistry and Molecular Biology, Saarland University, Homburg, Germany, Computational Biology, Saarland University, Saarbrücken, Germany and Experimental and Clinical Pharmacology and Toxicology, Saarland University, Homburg, Germany
منابع مشابه
BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER.
In mammalian cells, signal peptide-dependent protein transport into the endoplasmic reticulum (ER) is mediated by a dynamic protein-conducting channel, the Sec61 complex. Previous work has characterized the Sec61 channel as a potential ER Ca(2+) leak channel and identified calmodulin as limiting Ca(2+) leakage in a Ca(2+)-dependent manner by binding to an IQ motif in the cytosolic aminoterminus...
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